| Date | Home | Away | Result |
|---|---|---|---|
| 9/26/25 1:30 PM | CD Mirandes | Real Saragossa | 0-1 |
| 9/27/25 11:30 AM | SD Eibar | Deportivo La Coruna | 1-1 |
| 9/27/25 11:30 AM | Racing Santander | Andorra CF | 1-2 |
| 9/27/25 2:00 PM | UD Las Palmas | UD Almeria | 0-1 |
| 9/28/25 7:00 AM | Real Sociedad B | Cordoba CF | 1-1 |
| 9/28/25 9:15 AM | FC Cadiz | AD Ceuta FC | 0-0 |
| 9/28/25 9:15 AM | Burgos CF | FC Malaga | 2-1 |
| 9/28/25 11:30 AM | Real Valladolid | CyD Leonesa | 0-1 |
| 9/28/25 11:30 AM | Sporting Gijon | Albacete Balompie | 3-4 |
| 9/28/25 2:00 PM | SD Huesca | FC Granada | 0-1 |
| 9/29/25 1:30 PM | CD Leganes | CD Castellon | 0-1 |